Researchers pioneer world's first HIV/AIDS nanomedicines

Public release date: 29-Aug-2012
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Contact: Sarah Stamper
sarah.stamper@liv.ac.uk
01-517-943-044
University of Liverpool

Scientists at the University of Liverpool are leading a 1.65 million project to produce and test the first nanomedicines for treating HIV/AIDS.

The research project, funded by the Engineering and Physical Sciences Research Council (EPSRC), aims to produce cheaper, more effective medicines which have fewer side effects and are easier to give to newborns and children.

The new therapy options were generated by modifying existing HIV treatments, called antiretrovirals (ARVs). The University has recently produced ARV drug particles at the nanoscale which potentially reduce the toxicity and variability in the response different patients have to therapies. Drug nanoparticles have been shown to allow smaller doses in other disease areas which opens up possibilities to reduce drug side-effects and the risk of drug resistance. Nanoscale objects are less than one micron in size a human hair is approximately 80 microns in diameter.

Professor Steve Rannard, from the University's Department of Chemistry, said: "Nanomedicines are being used daily to treat a range of conditions around the world. There are, however, no current nanoparticle HIV therapies that are providing this kind of patient benefit. This project is the first step towards taking the nanomedicine options that we have developed out of our labs and into the clinic, representing a significant milestone in the development of new HIV treatments.

"If we can demonstrate real potential from our planned clinical work with healthy volunteers at the Royal Liverpool University Hospital, then our collaboration partner, IOTA NanoSolutions, will take forward the further development and clinical validation of the ARV drug particles in HIV patients. We also aim to test new formulations for children in developing countries, offering HIV patients around the world the prospect of safer, more effective treatments."

Professor Andrew Owen, from the University's Department of Molecular and Clinical Pharmacology, added: "We have integrated an assessment of pharmacology and safety early in the research and this has allowed us to rapidly progress lead options for clinical trials. The work has been conducted with the Medical Research Council (MRC) Centre for Drug Safety Science also based at the University."

"Our data so far looks really exciting, offering the potential to reduce the doses required to control the HIV virus. This work builds on initiatives by Mdecins Sans Frontires and other groups to seek ways to improve ARV therapy and could have real benefits for the safety of ARVs globally. Importantly we also hope to reduce the costs of therapy for resource-limited countries where the burden of disease is highest."

HIV continues to increase in prevalence, with 34 million people currently infected worldwide. The new HIV therapies offer particular hope for treating children with HIV which affects 3.4 million children under the age of 15 years in Sub Saharan Africa. About 90% of infected infants acquire the virus through mother-to-child transmission. Without treatment one third of children die within their first year of life.

There are currently very limited child-appropriate HIV drugs available and existing treatments carry a range of risks for the infant including under or over dosing. The new HIV nanomedicines from the Liverpool team disperse into water, which will make them easier to administer, particularly to newborn babies.

The project will manufacture the ARV nanomedicines using commercially relevant techniques under clinical grade manufacturing conditions. IOTA NanoSolutions was created to further develop and exploit technology originally developed at the University of Liverpool. The company operates a novel nanoparticle synthesis technology, ContraSol and is working with major global pharmaceutical companies. The ARV programme represents a further extension to the ongoing collaboration between the University of Liverpool and IOTA NanoSolutions.

The project aims to deliver highly valuable data within three years and provide a platform for continual development and testing during that time.

David Delpy, Chief Executive of the EPSRC, said: "The EPSRC is continuing its strong investment in nano-related research, which now permeates through almost every aspect of the engineering and physical sciences. This research may bring significant benefits to children infected with the HIV virus.

"It demonstrates how the vast potential of the fundamental science of nanotechnology is now being pulled through into engineering applications that help us address the societal challenges we face in healthcare and other areas."

The project builds on a previous collaboration funded by the Research Councils UK Nano Grand Challenge scheme.

###

Notes to editors:

1. The University of Liverpool is one of the UK's leading research institutions with an annual turnover of 410 million, including 150 million for research. Liverpool is ranked in the top 1% of higher education institutions worldwide and is a member of the Russell Group.

2. IOTA NanoSolutions Limited was registered as a spin-out company from Unilever in 2005 with funding from Unilever Ventures and a mission to develop and commercially exploit its novel proprietary nanodispersion technology, ContraSol. ContraSol offers opportunities to enhance performance of marketed drugs, NCEs and drug candidates currently in development and to revive promising discovery compounds previously overlooked owing to aqueous solubility. The company was co-founded by Prof. Steve Rannard, Dr. Alison Foster, Dr. Dave Duncalf and Prof. Andy Cooper. Since 2005, IOTA NanoSolutions occupies a suite of purpose-built laboratories in the MerseyBIO incubator in Liverpool, UK, from where it serves its growing portfolio of international clients.

3. "Mdecins Sans Frontires MSF (Doctors Without Borders) is an independent international humanitarian organisation that delivers emergency medical aid to people affected by armed conflict, epidemics, natural and man-made disasters or exclusion from health care in more than 60 countries around the world."

4. The Engineering and Physical Sciences Research Council (EPSRC) is the UK's main agency for funding research in engineering and the physical sciences. EPSRC invests around 800 million a year in research and postgraduate training, to help the nation handle the next generation of technological change. The areas covered range from information technology to structural engineering, and mathematics to materials science. This research forms the basis for future economic development in the UK and improvements for everyone's health, lifestyle and culture. EPSRC works alongside other Research Councils with responsibility for other areas of research. The Research Councils work collectively on issues of common concern via Research Councils UK. www.epsrc.ac.uk. For more information about the Nanotechnology Grand Challenges in healthcare visit: http://www.epsrc.ac.uk/funding/calls/2008/Pages/challenges.aspx

---

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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

Public release date: 29-Aug-2012
[ | E-mail | Share ]

Contact: Sarah Stamper
sarah.stamper@liv.ac.uk
01-517-943-044
University of Liverpool

Scientists at the University of Liverpool are leading a 1.65 million project to produce and test the first nanomedicines for treating HIV/AIDS.

The research project, funded by the Engineering and Physical Sciences Research Council (EPSRC), aims to produce cheaper, more effective medicines which have fewer side effects and are easier to give to newborns and children.

The new therapy options were generated by modifying existing HIV treatments, called antiretrovirals (ARVs). The University has recently produced ARV drug particles at the nanoscale which potentially reduce the toxicity and variability in the response different patients have to therapies. Drug nanoparticles have been shown to allow smaller doses in other disease areas which opens up possibilities to reduce drug side-effects and the risk of drug resistance. Nanoscale objects are less than one micron in size a human hair is approximately 80 microns in diameter.

Professor Steve Rannard, from the University's Department of Chemistry, said: "Nanomedicines are being used daily to treat a range of conditions around the world. There are, however, no current nanoparticle HIV therapies that are providing this kind of patient benefit. This project is the first step towards taking the nanomedicine options that we have developed out of our labs and into the clinic, representing a significant milestone in the development of new HIV treatments.

"If we can demonstrate real potential from our planned clinical work with healthy volunteers at the Royal Liverpool University Hospital, then our collaboration partner, IOTA NanoSolutions, will take forward the further development and clinical validation of the ARV drug particles in HIV patients. We also aim to test new formulations for children in developing countries, offering HIV patients around the world the prospect of safer, more effective treatments."

Professor Andrew Owen, from the University's Department of Molecular and Clinical Pharmacology, added: "We have integrated an assessment of pharmacology and safety early in the research and this has allowed us to rapidly progress lead options for clinical trials. The work has been conducted with the Medical Research Council (MRC) Centre for Drug Safety Science also based at the University."

"Our data so far looks really exciting, offering the potential to reduce the doses required to control the HIV virus. This work builds on initiatives by Mdecins Sans Frontires and other groups to seek ways to improve ARV therapy and could have real benefits for the safety of ARVs globally. Importantly we also hope to reduce the costs of therapy for resource-limited countries where the burden of disease is highest."

HIV continues to increase in prevalence, with 34 million people currently infected worldwide. The new HIV therapies offer particular hope for treating children with HIV which affects 3.4 million children under the age of 15 years in Sub Saharan Africa. About 90% of infected infants acquire the virus through mother-to-child transmission. Without treatment one third of children die within their first year of life.

There are currently very limited child-appropriate HIV drugs available and existing treatments carry a range of risks for the infant including under or over dosing. The new HIV nanomedicines from the Liverpool team disperse into water, which will make them easier to administer, particularly to newborn babies.

The project will manufacture the ARV nanomedicines using commercially relevant techniques under clinical grade manufacturing conditions. IOTA NanoSolutions was created to further develop and exploit technology originally developed at the University of Liverpool. The company operates a novel nanoparticle synthesis technology, ContraSol and is working with major global pharmaceutical companies. The ARV programme represents a further extension to the ongoing collaboration between the University of Liverpool and IOTA NanoSolutions.

The project aims to deliver highly valuable data within three years and provide a platform for continual development and testing during that time.

David Delpy, Chief Executive of the EPSRC, said: "The EPSRC is continuing its strong investment in nano-related research, which now permeates through almost every aspect of the engineering and physical sciences. This research may bring significant benefits to children infected with the HIV virus.

"It demonstrates how the vast potential of the fundamental science of nanotechnology is now being pulled through into engineering applications that help us address the societal challenges we face in healthcare and other areas."

The project builds on a previous collaboration funded by the Research Councils UK Nano Grand Challenge scheme.

###

Notes to editors:

1. The University of Liverpool is one of the UK's leading research institutions with an annual turnover of 410 million, including 150 million for research. Liverpool is ranked in the top 1% of higher education institutions worldwide and is a member of the Russell Group.

2. IOTA NanoSolutions Limited was registered as a spin-out company from Unilever in 2005 with funding from Unilever Ventures and a mission to develop and commercially exploit its novel proprietary nanodispersion technology, ContraSol. ContraSol offers opportunities to enhance performance of marketed drugs, NCEs and drug candidates currently in development and to revive promising discovery compounds previously overlooked owing to aqueous solubility. The company was co-founded by Prof. Steve Rannard, Dr. Alison Foster, Dr. Dave Duncalf and Prof. Andy Cooper. Since 2005, IOTA NanoSolutions occupies a suite of purpose-built laboratories in the MerseyBIO incubator in Liverpool, UK, from where it serves its growing portfolio of international clients.

3. "Mdecins Sans Frontires MSF (Doctors Without Borders) is an independent international humanitarian organisation that delivers emergency medical aid to people affected by armed conflict, epidemics, natural and man-made disasters or exclusion from health care in more than 60 countries around the world."

4. The Engineering and Physical Sciences Research Council (EPSRC) is the UK's main agency for funding research in engineering and the physical sciences. EPSRC invests around 800 million a year in research and postgraduate training, to help the nation handle the next generation of technological change. The areas covered range from information technology to structural engineering, and mathematics to materials science. This research forms the basis for future economic development in the UK and improvements for everyone's health, lifestyle and culture. EPSRC works alongside other Research Councils with responsibility for other areas of research. The Research Councils work collectively on issues of common concern via Research Councils UK. www.epsrc.ac.uk. For more information about the Nanotechnology Grand Challenges in healthcare visit: http://www.epsrc.ac.uk/funding/calls/2008/Pages/challenges.aspx

---

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?

AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

Source: http://www.eurekalert.org/pub_releases/2012-08/uol-rpw082912.php

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Police: Md. teen brought shotgun, vodka to school

Tracie Bradford, of Perry Hall, Md., consoles her daughter Leah, a student at Perry Hall High School who says she was in the school's cafeteria when a student was shot there and critically wounded on the first day of classes, Monday, Aug. 17, 2012, in Perry Hall, Md. A suspect was taken into custody shortly after the shooting, according to police. No one else was reported injured. (AP Photo/Steve Ruark)

Tracie Bradford, of Perry Hall, Md., consoles her daughter Leah, a student at Perry Hall High School who says she was in the school's cafeteria when a student was shot there and critically wounded on the first day of classes, Monday, Aug. 17, 2012, in Perry Hall, Md. A suspect was taken into custody shortly after the shooting, according to police. No one else was reported injured. (AP Photo/Steve Ruark)

Becky Hobgood tries to locate her daughter after a student was shot and critically wounded on the first day of classes Perry Hall High School, Monday, Aug. 27, 2012, in Perry Hall, Md. A suspect was taken into custody shortly after the shooting, according to police. No one else was reported injured. (AP Photo/Steve Ruark)

Students evacuate Perry Hall High School after a student was shot and critically wounded on the first day of classes Monday, Aug. 27, 2012, in Perry Hall, Md. A suspect was taken into custody shortly after the shooting, according to police. No one else was reported injured. (AP Photo/Steve Ruark)

Parents and students try to reunite after a student was shot and critically wounded on the first day of classes at Perry Hall High School, Monday, Aug. 27, 2012, in Perry Hall, Md. A suspect was taken into custody shortly after the shooting, according to police. No one else was reported injured. (AP Photo/Steve Ruark)

Parents and students try to find each other after a student was shot and critically wounded on the first day of classes at Perry Hall High School Monday, Aug. 27, 2012, in Perry Hall, Md. A suspect was taken into custody shortly after the shooting, according to police. No one else was reported injured. (AP Photo/Steve Ruark)

PERRY HALL, Md. (AP) ? A 15-year-old sophomore at a suburban Baltimore high school who made references to murder-suicide on Facebook has been charged as an adult in the shooting of a classmate on the first day of school, authorities said Tuesday.

Robert Wayne Gladden Jr. was being held without bail on charges of attempted first-degree murder and first-degree assault, Baltimore County police said. A preliminary hearing was scheduled for Sept. 7. The state's attorney's office did not know if he had a lawyer.

Gladden's last status update on his Facebook page, posted the morning of the shooting, read: "First day of school, last day of my life. ... f--- the world."

His father told The Associated Press that his son had been bullied. Baltimore County Police Chief James Johnson said at a news conference Tuesday that he was aware of the reported bullying, but he said Gladden has not indicated in conversations with detectives that bullying was a motive for the shooting. He did not disclose other possible motives.

Gladden continues to cooperate with investigators and was undergoing a mental health evaluation, Johnson said.

Gladden rode to school on the bus Monday morning with a bag containing a disassembled shotgun, 21 rounds of ammunition and a bottle of vodka, Johnson said.

When he arrived at school, Gladden went to his first two classes, Johnson said. On the way to the cafeteria, he stashed the bag with the shotgun in a restroom, the chief said. A short time later, he returned to the restroom and assembled the gun, which he then hid beneath his clothes, Johnson said.

Upon entering the cafeteria, he pulled out the gun and fired a shot toward a lunch table, according to charging documents. A 17-year-old classmate, Daniel Borowy, was struck in the back.

Teachers and school staff then rushed toward the teen, and in the ensuing struggle, he fired another shot that hit the ceiling, investigators said in the documents. The staffers were able to get the gun away from him and he was arrested by a school resource officer.

Witnesses credited guidance counselor Jesse Wasmer with getting the gun away from Gladden.

Gladden sipped from the vodka bottle before the shooting but did not drink enough to become intoxicated, Johnson said.

The teen obtained the shotgun from his father's house, Johnson said. The weapon was manufactured before 1968 and was of legal length, and police were trying to determine whether it was properly registered, he said.

On his Facebook page, Gladden referred to mass murderer Charles Manson and gave himself the nickname "SuicidalSmile." The page, identified by classmates as belonging to the suspected shooter, was just launched in July, and the three photos of Gladden all show his face hidden behind long, dark hair. He describes himself as a "metalhead" and a fan of musicians Marilyn Manson and Slipknot.

The suspect's father, Robert W. Gladden, told the AP Monday evening that his son was the shooter and indicated his son had been bullied. He gave no further details.

A woman who was also at the home in Middle River and said she was related to the elder Gladden gave the following statement on the family's behalf: "We are horrified. We did not see this coming and our thoughts and prayers are with the victim and the victim's family."

Borowy remained in critical condition Tuesday at Maryland Shock Trauma Center, a hospital spokeswoman said. His family issued a statement asking well-wishers to keep him in their thoughts and prayers and asking for privacy.

Police also executed a search warrant at the Kingsville home of Gladden's mother and stepfather and arrested the stepfather ? Andrew Piper, 43 ? on illegal gun and drug possession charges, police said. The charges against Piper had nothing to do with the school shooting, Johnson said, but he noted that Gladden lived part-time at that address.

Classes resumed Tuesday at the school amid a low-key police presence. About 150 students turned out for a prayer vigil organized by local churches on the school grounds. Some students wore T-shirts and bracelets reading "Pray for Daniel" and "Team Wasmer" in reference to the victim and the guidance counselor.

Shane Boyer, 44, who was dropping off his 13-year-old daughter Corinne, said the vigil helped calm students still dealing with the shooting. Boyer said he knew immediately that his daughter was safe after the shooting because he received text messages from her. One read, "Someone just shot a gun in lunch," followed by another that said, "I ran out I am do (sic) scared there's helicopters + cops + we are all outside."

___

Nuckols reported from Washington.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/386c25518f464186bf7a2ac026580ce7/Article_2012-08-28-High%20School%20Shooting/id-07a15a2bf3a1496e8d3b8d1efbedc0c8

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Dhakku Blog - Maximising Social Media: Enterprises Create ...

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Posted by Eta Phi Sports on Aug 28, 2012 in Mobile | 0 comments

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Video: Rachel Maddow Digs Into the Origins of Todd Akin's Weird Biology (Little green footballs)

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50 buildings destroyed in Northern Calif. fire

MANTON, Calif. (AP) ? Dozens of buildings, many of them likely homes, have been destroyed in recent days a fire burning outside the Northern California community of Manton, fire officials said Tuesday night.

Fire crews assessing the rural area determined Tuesday that 50 buildings had been destroyed, state fire spokesman Daniel Berlant said. The count included buildings burned since the fire began, but officials did not say when the structures were destroyed.

Officials didn't have an accurate count yet of how many of the structures were homes, but Berlant noted the buildings were spread across a vast rural area of mostly residential homes.

The blaze, which was sparked by lightning on Saturday has consumed more than 33 square miles and continues to threaten hundreds of homes.

Nearly 1,900 firefighters were battling the fire in rugged, densely forested terrain as it threatened 3,500 homes in the remote towns of Shingletown, Manton and Viola, about 170 miles north of Sacramento.

As a the wildfire raged near Lynn Rodgers' home of less than a year, the evacuated resident said Tuesday she remained optimistic ? in spite of her growing frustration and fear.

"Yeah, but what can you do? Everything is in God's hands ? and the firefighters," said Rodgers, who lives in Shingletown.

Like Rodgers, many other evacuees were anxious to hear the latest information from officials. Dozens of people, as well as about a dozen dogs, were waiting at the Redding gym.

"The evacuation part? It's hard because I don't know what's happening to the house up there," said Jimmy Hall, a Shingletown resident whose family spent another night sleeping on cots.

"It's my dad's house...There's a lot of things in there," Hall added. "I've heard that my friend is still up there protecting his house. It's just hard. Look at how we're sleeping."

Eric Kiltz, an emergency services coordinator for the American Red Cross, said "there's more frustration than anxiety, and people, for the most part are grateful they have a safe and secure place to stay, even though their home may be lost."

The fast-moving fire is one of many burning across the West, where dry lightning has sparked up grass, brush and timber, bringing an early start to the fire season.

Gov. Jerry Brown announced Tuesday that National Guard troops will be assisting with the firefighting efforts. The news comes a day after the Federal Emergency Management Agency said it is offering federal funds to help fight the blaze.

The fire forced the closure of Highway 44 and other roads, and prompted the declaration of an emergency in Shasta County.

Elsewhere in California, a massive wildfire in Plumas National Forest continued to expand, helped by gusty winds. The blaze, about 120 miles north of Sacramento, has consumed nearly 98 square miles since it started at the end of July and threatens about 900 homes.

In Mendocino County, the sheriff's office issued a mandatory evacuation for residents in Covelo due to a wildfire that has burned more than 15 square miles of thick timber and rugged terrain. One outbuilding has been destroyed and 45 homes were threatened by the blaze, officials said. The fire was sparked by lightning Saturday in a remote area, making it difficult for fire crews to access.

In Washington state, the National Weather Service warned about extreme fire danger in the eastern part of the state as forecasts called for thunderstorms with lightning.

Fire crews to the north were still hoping to fully contain a week-old wildfire that has destroyed 51 homes and 26 outbuildings, and damaged at least six other homes, fire information officer Mark Morrow said.

The fire, about 75 miles east of Seattle, has caused an estimated $8.3 million in property damage.

Lightning over the weekend also sparked smaller fires in Colorado, Idaho and Utah.

___

Collins reported from San Francisco. Associated Press writers John S. Marshall in San Francisco, Lynn DeBruin in Salt Lake City, Shannon Dininny in Yakima, Wash., and Jessie Bonner in Boise, Idaho, contributed to this report.

Source: http://news.yahoo.com/50-buildings-destroyed-northern-calif-fire-035715498.html

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Molecular code of PPR proteins cracked

Monday, August 20, 2012

The code determines the recognition of RNA molecules by a superfamily of RNA-binding proteins called pentatricopeptide repeat (PPR) proteins.

When a gene is switched on, it is copied into RNA. This RNA is then used to make proteins that are required by the organism for all of its vital functions. If a gene is defective, its RNA copy and the proteins made from this will also be defective. This forms the basis of many terrible genetic disorders in humans.

RNA-binding PPR proteins could revolutionise the way we treat disease. Their secret is their versatility - they can find and bind a specific RNA molecule, and have the capacity to correct it if it is defective, or destroy it if it is detrimental. They can also help ramp up production of proteins required for growth and development.

The new paper in PLOS Genetics describes for the first time how PPR proteins recognise their RNA targets via an easy-to-understand code. This mechanism mimics the simplicity and predictability of the pairing between DNA strands described by Watson and Crick 60 years ago, but at a protein/RNA interface.

This exceptional breakthrough comes from an international, interdisciplinary research team including UWA researchers Professor Ian Small and Aaron Yap from the ARC Centre for Excellence in Plant Energy Biology and Professor Charlie Bond and Yee Seng Chong from UWA's School of Chemistry and Biochemistry, along with Professor Alice Barkan's team at the University of Oregon. This research was publicly funded by the ARC and the WA State Government in Australia and the NSF in the USA.

"Many PPR proteins are vitally important, but we don't know what they do. Now we've cracked the code, we can find out," said ARC Plant Energy Biology Director Ian Small.

"What's more, we can now design our own synthetic proteins to target any RNA sequence we choose - this should allow us to control the expression of genes in new ways that just weren't available before. The potential is really exciting."

"This discovery was made in plants but is applicable across many species as PPR proteins are found in humans and animals too," says Professor Bond.

###

Article: http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1002910

University of Western Australia: http://www.uwa.edu.au

Thanks to University of Western Australia for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

This press release has been viewed 51 time(s).

Source: http://www.labspaces.net/122728/Molecular_code_of_PPR_proteins_cracked

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work for black women during the 1950s | Black Dating

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work for black women during the 1950s Federal Work Programs for Black Americans Documentary (1930s) work for black women during the 1950s

work for black women during the 1950s Federal Work Programs for Black Americans Documentary (1930s) ? 1930s Government Newsreel (?We Work Again?) of how the WPA put Black Americans back to working again during the height of the Great Depression. The narrator states that they are the first to lose jobs and the last to be rehired. 10% of the nation is black, while 16% is unemployed and 25% on relief. These are the grandparents of Baby Boomer aged kids. Watch and decide for yourself how these conditions and other events lead to the great racial riots of the 1960?s that all Baby Boomers live through. Catch the following irony: A white narrator extolling how ?we? have suffered but now have dignity again. The long and medium shots show integrated work situations but the close-ups only show Blacks in close proximity to other Blacks unless the white person is in a supervisor relationship. Black teachers only teach Black students, Black nurses only care for Black patients. The newsreel takes pride in pointing out that the Federal Government trains Black women to be domestics. This film has been edited for time and content. It is part of the Prelinger Public Domain. Check out more memories of growing up in the 1950s, 60s and beyond at www.babyboomerstories.com ? Federal Work Programs for Black Americans Documentary (1930s) work for black women during the 1950s

work for black women during the 1950s

This entry was posted in and tagged black, cool, dress, guitar, long, tabs, woman by Anderson. Bookmark the permalink.

Source: http://aglomot.com/work-for-black-women-during-the-1950s-2/

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Social Media Marketing: 3 Hints You Are Doing It Right!

Last updated 16 hours ago

Having a Facebook page for your small business may seem as ubiquitous as having a website ? but not all companies use the digital space to its full potential. Social media affords smaller businesses the opportunity to organically grow a customer base with a humble marketing budget. Here is a look some hints for determining if your business is doing social media marketing right:

1. Your Fans Are Engaged

If your company?s social media updates are inspiring conversations and thoughtful discussions by fans ? then you are on the right track. Fan engagement can have a number of different facets depending on your type of business and digital presence, but keeping former and future customers involved is key to broadening your online reach. To encourage fan engagement, be sure to use the ?@? mention symbol to create more interactive updates. Try also to ask leading questions and post photos and links that will spark a conversation.

2. The Metrics Are Looking Good

A great way to measure your social media impact is through data analytics. Does your company have exponentially more Facebook likes now than a year ago? Is overall website viewership up due to social media referrals? Do your tweets inspire an average number of replies and retweets? If so, you are likely using social media to its marketing potential! Be sure to sign up for Google Analytics, which can measure the referral traffic from Twitter and Facebook to your website.

3. Sales Are Up

One of the main benefits of using social networks is their power to help your bottom line grow. A good way to know if you are doing social media right is increased sales, greater foot traffic, or higher profits. These results can occur through through better brand recognition, word of mouth marketing, or increased repeat business from fans. Better sales indicate that your digital outreach is having a positive effect in today?s connected marketplace.

Not all businesses can maximize social media marketing on their own. If you?d like professional help creating and implementing a digital outreach strategy for your unique company and market, contact ReachLocal strategist Brad Sharenow. Brad can help your New York City business with online marketing and social media. Call (877) 411-3777 to schedule a free strategy session with Brad.

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Source: http://www.onlinemarketingconsultantnyc.com/525464/2012/08/20/social-media-marketing-3-hints-you-are-doing-it-right!.html

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Online Relationship Advice Online - 24-7 Help When It's Needed ...

Online Relationship Advice Online - 24-7 Help When It's Needed
If you've been facing problems inside your marriage or sex life, you'll find relationship advice
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will find blends of excellent advice and bad advice. Lots of people online will give you bad suggest
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will let you find the ideal person, or may aid you in getting from a relation that you simply feel is
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greatest. You may want to talk with your close buddies and family you never penile extender know
and knows your circumstances, however they may act partial, because they adore you. You may
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The good thing of having online advice is you get support 24 hrs each day for seven days a week.
For example, something might have happened that may cause being dumped, then rather than
putting things off counting your roofs, you are able to instantly get advice. You will find articles
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The good thing of seeking relationship advice online online is you can keep your discretion. You
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place for relationship advice online. You could get helpful advice online when you search the web.

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Source: http://pdfcast.org/pdf/online-relationship-advice-online-24-7-help-when-it-s-needed

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16 severed hands unearthed ? all rights

A team of archaeologists excavating a palace in the ancient city of Avaris, in Egypt,? has made a gruesome discovery.

The archaeologists have unearthed the skeletons of 16 human hands buried in four pits. Two of the pits, located in front of what is believed to be a throne room, hold one hand each. Two other pits, constructed at a slightly later time in an outer space of the palace, contain the 14 remaining hands.

They are all right hands; there are no lefts.

"Most of the hands are quite large and some of them are very large," Manfred Bietak, project and field director of the excavations, told LiveScience.

The finds, made in the Nile Delta northeast of Cairo, date back about 3,600 years to a time when the Hyksos, a people believed to be originally from northern Canaan, controlled part of Egypt and made their capital at Avaris? a location known today as Tell el-Daba. At the time the hands were buried, the palace was being used by one of the Hyksos rulers, King Khayan.? [See Photos of the Buried Hands]

1. Science news from NBCNews.com

   1. Roman ship found laden with cargo

      A Roman trading ship from the time of the Caesars has been discovered off the coast of Italy, reportedly in such good condition that some of the food may still be preserved.

   2. Bizarre crystal may have zipped here from space
   3. Wet feet wash away geckos' stickiness
   4. Reports on animal sex found troubling

The right hand
The hands appear to be the first physical evidence of a practice attested to in ancient Egyptian writing and art, in which a soldier would present the cut-off right hand of an enemy in exchange for gold, Bietak explains in the most recent edition of the periodical Egyptian Archaeology.

"Our evidence is the earliest evidence and the only physical evidence at all," Bietak said. "Each pit represents a ceremony."

Cutting off the right hand, specifically, not only would have made counting victims easier, it would have served the symbolic purpose of taking away an enemy's strength. "You deprive him of his power eternally," Bietak explained.

It's not known whose hands they were; they could have been Egyptians or people the Hyksos were fighting in the Levant. [The History of Human Combat]

"Gold of valor"
Cutting off the right hand of an enemy was a practice undertaken by both the Hyksos and the Egyptians.?

One account is written on the tomb wall of Ahmose, son of Ibana, an Egyptian fighting in a campaign against the Hyksos. Written about 80 years later than the time the 16 hands were buried, the inscription reads in part:?

"Then I fought hand to hand. I brought away a hand. It was reported to the royal herald." For his efforts, the writer was given "the gold of valor" (translation by James Henry Breasted, Ancient Records of Egypt, Volume II, 1905). Later, in a campaign against the Nubians, to the south, Ahmose took three hands and was given "gold in double measure," the inscription suggests.

Scientists are not certain who started this gruesome tradition. No records of the practice have been found in the Hyksos' likely homeland of northern Canaan, Bietak said, so it could have been an Egyptian tradition they picked up, or vice versa, or it could have originated from somewhere else.?

Bietak pointed out that, while this find is the earliest evidence of this practice, the grisly treatment of prisoners in ancient Egypt was nothing new. The Narmer Palette, an object dating to the time of the unification of ancient Egypt about 5,000 years ago, shows decapitated prisoners and a pharaoh about to smash the head of a kneeling man.?

The archaeological expedition at Tell el-Daba is a joint project of the Austrian Archaeological Institute?s Cairo branch and the Austrian Academy of Sciences.

Follow LiveScience on Twitter @livescience. We're also on Facebook? and Google+.

? 2012 LiveScience.com. All rights reserved.

Source: http://www.msnbc.msn.com/id/48612904/ns/technology_and_science-science/

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Golfing Health Exercises For the Junior Golfer | GC Community Online

Adult men about the PGA Tour and most women near. Thoughts like what accurately are the most beneficial exercises to greatly enhance golfing physical fitness levels, are overall flexibility physical exercises and stretches considerably more effective than other forms of golfing health and fitness exercises, and what would be the gains of golf health workout routines for that woman golfer. These and a large number of problems surround the matter of golfing exercise. Is there a big difference relating to the LPGA player as nicely as the beginner lady golfer in relation to golfing conditioning exercise The solution is no. The skeletal, muscular, and neural solutions are the precise equivalent. The expert golfer has the similar amount of muscle groups inside their bodies as the beginner. Subsequently of the physique getting the similar, the thoughts and design of the golfing exercise schedule for any girl is similar. The rather 1st basic principle to figure out a few golfing health and fitness system is jeu a number of. A golf exercises seems to develop and develop in relation to the golfing swing. Distraction specific can be a phrase describing the sort of schooling put into use in a golfing physical fitness prepare. A 2nd principle with care relevant to divertissement pursuits unique coaching is cross specificity coaching. The aim of cross specificity coaching is quite often a transfer of coaching result in the direction of the field of rivals. Given that the lady golfer increases her versatility parameters in relation toward the golfing swing. This advantage is an illustration of a transfer of training bearing onto the golfing software. In summary, the three concepts that support inside the progression of the golfing health and fitness program for girls are sports activities selected, cross specificity coaching, and transfer of workout effect. Outside from the suggestions governing the development of a golfing exercise platform for woman. Dont forget, it really is the overall body performing the biomechanics from the golf swing.

This is really quite potentially a burning up need to have of most. just a person for this secrets to making golf the straighter and a good deal more time can be a golf bodily health plan. An beginner a brief while ago despatched me an e-mail describing how he?s making the golf far more time and straighter than at any time earlier than. He plainly states the excellent explanation for that improvement is right away relevant to some golfing physical physical fitness software program he carried out 10 months back. staying a reward for my endeavours and development, I purchased a manufacturer identify new Ping visit wedge. quickly as a result of I can previously see i?m hitting my drives routinely a full good deal straighter. And, i?m a entire ton far further persistent with my pitches and chips. The only stage i?m uncertain of is "am I pushing myself ample? I know I have not pushed myself on some the exercise sessions like side Holds as I will have to have to have the final result getting no progress with this. We specified objectives to golf workout addition targets have a several benefit. For my primary targets i?ve five months to go, if I skip these then Mid-Might possibly will be subsequent deadline. it will be simply just considering the fact that of one?s demanding work and willpower toward the golf bodily fitness applications your golf video clip game is improving." I suggestion my hat to you. i know Phil and just about nearly every one sportsman I function with models objectives. On just an individual hand, it permits you to evaluate oneself and look for out how you can be progressing. are not most of us trying to decrease our handicaps. By Kwzrest riuyond

Parchment is a skinny material crafted from calfskin, sheepskin or goatskin. Bookbinders in several years gone by attempted many approaches to design imitation parchments and vellums using paper as the commencing stage, as the legitimate content was fantastic but tremendously expensive. All we are heading to would need is some shellac flakes and liquor. Of training course if you want to use the parchment paper as a book covering material, just simply apply the varnish to the paper and use as parchment paper. When the shellac has all dissolved the varnish is prepared to use. The varnish will have transformed the Parchment Sheets look and truly feel of the paper. If you know tiny about paper allow me manual you to the proper style. By a good fibre furnish I necessarily mean that a good high-quality paper fibre was used in its building. A different paper which makes an terrific parchment paper is made by a enterprise generally known as Hahnemuhle, it is termed Medieval Laid and is accessible in One time you have your varnish and paper all set, lay down some squander paper. We are simply going to give our sheet of paper a generous coat of varnish, use a paintbrush or paint roller. When you can see that the paper is saturated with the varnish, raise it and position.

This entry was posted in Uncategorized. Bookmark the permalink.

Source: http://www.gc-community.net/golfing-health-exercises-for-the-junior-golfer/

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Best Buy Gaming Blowout 2.0 clearance event info leaked-Computer

A couple of weeks ago Best Buy held a ?Gaming Blowout? clearance event that places many games and accessories for $14.99 or less, and in many cases (for accessories) $1.99 or less. ?Rumors of a Gaming Blowout 2.0 surfaced earlier this week and appear to be confirmed for the week of 8/12, though not all the sale information is yet known. ?So far the employee who leaked the information displayed in the sale ad stated that the following was included:

The Darkness II ? $14.99 ? Read our review!
Sorcery ? $14.99
Skylanders 3-Character Pack ? $14.99
The Black Eyed Peas Experience ? $9.99
Rayman Origins ? $9.99
Street Fighter IV 3D Edition ? $9.99
Rocketfish 4 port Charging Station for PS3 ? $4.99
Playstation Move Shooting Pistol ? $4.99
160Gb Playstation 3 ? $229.99

Also rumored but at this point completely unconfirmed for the sale is the following list:

Uncharted Dual Pack
Uncharted 3 ? Read our Review!
Batman Arkham City
UDraw ?Something or Another?
Resistance 3
AC Brotherhood

Last time around many titles were not known till only minutes before the sale went live on BestBuy.com and that is likely to be true again this time. We will update this post with any additional information as it becomes available. ?CAG user MidnightMetal is responsible for confirming the rumored sale.

Source: http://ob-game.blogspot.com/2012/08/best-buy-gaming-blowout-20-clearance.html

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The Rural Stops: Why You Need To Outsource Call Center Work

One of the best ways for a business to save money nowadays is to outsource call center work to offshore companies or individuals. Almost all kinds of companies, large and small, stand to benefit from outsourcing their inbound and outbound customer service functions. Companies currently thrive in a highly competitive business environment. If you want to get ahead of your competitors then it is a must that your are always in touch with your customers. Having a call center is the most effective way for you to be accessible to your customers With a call center, you can keep your customers satisfied and you can make them feel important by addressing their queries and by helping them deal with their problems. Call centers can also take orders of products or book service requests. It is a very worthy investment that can benefit all types of companies.

When your business is small, it is very possible that you can handle call center work on your own. As your business grow though, the need for an improved system of customer support becomes apparent. Businesses normally find it hard to handle customer relations themselves and this is why there is a great need to outsource call center work. The best place to outsource work is in developing countries where there is an abundance of cheap yet high quality workforce. Countries such as the Philippines and India are home to highly skilled and trained call center agents that are not only adept in customer service skills but are also fluent in spoken and written English. Another advantage of countries such as the Philippines is the presence of reliable telecommunications infrastructure that assures stable and uninterrupted business transactions.

One of the greatest advantage that you will experience if you will outsource call center work to offshore companies and individuals is of course the savings in terms of money. It is a fact that the cost of labor in developing countries is much cheaper than what it costs in Western and developed countries. Some companies who have employed outsourcing as a business strategy were able to save as much as 70% of their workforce-related expenses. This is the reason why outsourcing is such a hot trend and why everybody seem to be jumping on the bandwagon. Ultimately though, what outsourcing brings to a company is greater efficiency as it frees up time, money and other valuable resources which can then be used for other more productive pursuits and aspects of the business.

If you will outsource call center work, you can also expect to encounter problems. Sometimes, cultural and language issues can affect the way you do business with offshore companies. But the advantages of outsourcing greatly outweighs the cons. And the risk of not outsourcing is actually greater than the challenges that a company will face if it does decide to outsource.

To outsource call center work is something that companies the world over must do in order to grow and thrive in the 21st Century.

----------------------------------------------------
In this industry call center customer satisfaction (Csat) is king. If you are not focused on customer satisfaction then you're dropping the ball. Using IVR surveys to gather your customer's opinions will go a long towards helping you understand how to improve your call center Csat.

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Source: http://ruralstops.blogspot.com/2012/08/why-you-need-to-outsource-call-center.html

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